Compétition mRNA/miRNA et croissance de mélanome

A non-coding function of TYRP1 mRNA promotes melanoma growth.

Gilot D, ... Montier T.,... Galibert MD
Nat Cell Biol. 2017 Nov;19(11):1348-1357.(accès abonné à Nature)

 In this study, we uncover the mechanism by which TYRP1 mRNA can sequester miR-16, thereby governing a specific gene expression program that promotes melanoma growth. These data have broad implications both for our understanding of cancer biology and for the development of targeted therapeutics.